产品货号：
Z27017
中文名称：
SNAP25抗体
英文名称：
Anti-SNAP25 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SNAP25 Antibody |
| 指标别名 | RIC 4;RIC4;SEC9;SNAP;SNAP 25;SNAP25;SUP;Super protein |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | SNAP25 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human SNAP25(186-200aa DSNKTRIDEANQRAT),identical to the related rat and mouse sequences. |
| 实际分子量 | 25KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Synaptosome-associated protein of 25,000 daltons also known as SNAP-25 is a protein which in humans encodes a 25-kD protein of 206 amino acids.It was first investigated as a neuron-specific gene preferentially expressed in mouse hippocampus.The tSNARE(the target-membrane soluble NSF-attachment protein receptor,where NSF is N-ethylmaleimide-sensitive fusion protein) synaptosomal-associated protein of 25kDa(SNAP-25) is expressed in pancreatic B-cells and its cleavage by botulinum neurotoxin E(BoNT/E) abolishes stimulated secretion of insulin.In the nervous system,two SNAP-25 isoforms(a and b) have been described,which are produced by alternative splicing.Nagy et al.(2004) identified mammalian Snap25a and Snap25b as targets of protein kinase A,a key regulator of neurosecretion that primes slowly releasable pools and readily releasable pools of secretory vesicles.SNAP-25 inhibits P/Q- and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion.In glutamatergic synapses SNAP-25 decreases the Ca2+ responsiveness,while it is naturally absent in GABAergic synapses. |
| Uniprot ID | P60880 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | synaptosomal-associated protein,25kDa |
| 蛋白名全称 | Synaptosomal-associated protein 25(SNAP-25) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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